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學校名稱輔仁大學
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研究生(中)李秉恆
研究生(英)Ping-Heng Li
論文名稱(中)硫取代之吲啶衍生物的合成研究
論文名稱(英)Synthetic Approaches to Sulfur-substituted Indolizidines
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指導教授(中)周善行
指導教授(英)Shang-Shing Chou
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畢業學年度94
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關鍵字(中)硫取代之吲啶衍生物的合成研究
關鍵字(英)Synthetic Approaches to Sulfur-substituted Indolizidines
摘要(中)本論文利用本實驗室之前所合成出的化合物15進行一些官能基的轉換，合成了產物18-30，但未能順利切除Bn基。然而發現2-苯硫基 -1,3-丁二烯與imino-ester 31可順利進行 [4+2] 環化加成反應得到產物 32，並成功地合成出Indolizidine的化合物36。另外，1-甲基-3-苯硫基-1,3-丁二烯 (37) 與imino-ester 31進行 [4+2] 環化加成反應得到順反異構物38，將探討反應條件對立體化學的影響。
摘要(英)This thesis studied various functional group transformations of compound 15. Products 18-30 were obtained. However, the benzyl group of 15 could not be effectively cleaved. On the other hand, we discovered a new aza-Diels-Alder reaction of imino-ester 31 with 2-(phenylthio)- 1,3-butadiene to give product 32. After suitable functional group transformations, compound 32 was successfully converted to indolizidine 36. A similar reaction of imino-ester 31 with 1-methyl-3-(phenythio)- 1,3-butadiene (37) gave a mixture of cis/trans cycloaddition products 38. Factors affecting the stereochemistry of the reaction will be studied.
論文目次目錄 中文摘要………………………………………………………i 英文摘要………………………………………………………ii 緒 論……………………….……………………………... 1 本論文研究目標……………..………………………...………7 結果與討論……………………………………..……………...9 結 論………………………………………………….…..23 使用之儀器、藥品和溶劑………………………………………..24 實驗步驟與光譜數據…………………………………….…..27 參考文獻……………………………………………….….….62 附錄…………………………………………………….….….66
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