參考文獻 | 邱麗慧。1999。農桿菌轉殖阿拉伯芥CBF1基因於番茄之研究。國立師範大學生物研究所碩士論文。
黃建豪。2002。基因轉殖植物生產人類血清蛋白。國立東華生物技術研究所碩士論文。
葉怡鈴。2002。介白素12基因在過敏疾病治療及免疫調節機制之探討。國立台灣大學免疫學研究所博士論文。
Boggio K, Nicoletti G, Di Carlo E, Cavallo F, Landuzzi L, Melani C, Giovarelli M, Rossi I, Nanni P, De Giovanni C, Bouchard P, Wolf S, Modesti A, Musiani P, Lollini PL, Colombo MP, Forni G (1998) Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J Exp Med 188: 589-596
Bretthauer RK (2003) Genetic engineering of Pichia pastoris to humanize N-glycosylation of proteins. Trends Biotechnol 21: 459-462
Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G (1991) Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 173: 869-879
Chen TL, Lin YL, Lee YL, Yang NS, Chan MT (2004) Expression of bioactive human interferon-gamma in transgenic rice cell suspension cultures. Transgenic Res 13: 499-510
Clerici M, Shearer GM (1993) A TH1-->TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 14: 107-111
Cortina C, Culianez-Macia FA (2004) Tomato transformation and transgenic plant production. Plant Cell Tissue Organ Cult 76: 269-275
Costa MGC, Noguera FTS, Figueira ML, Ontoni WC, Brommonoshenkel SH, Cecon PR (2000) Influence of the antibiotic timentin on plant regeneration of tomato (Lycopersicon esculentum Mill) cultivars. Plant Cell Rep 19: 327-332
Coyle AJ, Le Gros G, Bertrand C, Tsuyuki S, Heusser CH, Kopf M, Anderson GP (1995) Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cell Mol Biol 13: 54-59
D'Andrea A, Rengaraju M, Valiante NM, CHehimi J, Kubin M, Aste-Amezaga M, Chan SH, Kobayashi M, Young D, Nickbarg E, Chizzonite R, Wolf SF, Trinchieri G (1992) Production of nature killer cell stimulatory factor (Interleukin 12) by peripheral blood mononuclear cells. J Exp Med 176: 1387-1398
Daniell H, Chebolu S, Kumar S, Singleton M, Falconer R (2005) Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine 23: 1779-1783
Daniell H, Streatfield SJ, Wycoff K (2001) Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 6: 219-226
Douglas CJ, Halperin W, Nester EW (1982) Agrobacterium tumefaciens mutants affected in attachment to plant cells. J Bacteriol 152: 1265-1275
Eklund KK, Ghildyal N, Austen KF, Stevens RL (1993) Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J Immunol 151: 4266-4273
Filichkin SA, Gelvin S (1993) Formation of a putative relaxation intermediate during T-DNA processing directed by the Agrobacterium tumefaciens VirD1,D2 endonuclease. Mol Microbiol 8: 915-926
Fischhoff DA, Bowdish KS, Perlak FJ, Marrone PG, McCormick SM, Niedermeyer JG, Dean DA, Kusano-Kretzmer K, Mayer EJ, D.E. R, Rogers SG, Fraley RT (1987) Insect Tolerant Transgenic Tomato Plants. Bio Technology 5: 807-813
Flynn JL, Goldstein MM, Triebold KJ, Sypek J, Wolf S, Bloom BR (1995) IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 155: 2515-2514
Fraley RT, Rogers SG, Horsch RB, Sanders PR, Flick JS, Adams SP, Bittner ML, Brand LA, Fink CL, Fry JS, Galluppi GR, Goldberg SB, Hoffmann NL, Woo SC (1983) Expression of bacterial genes in plant cells. Proc Natl Acad Sci U S A 80: 4803-4807
Frary A, Earle ED (1996) An examination of factor affecting the efficiency of Agrobacterium-mediated transformation of tomato. Plant Cell Rep 16: 235-240
Galvao da Silva AP, de Almeida Abrahamsohn I (2001) Interleukin-12 stimulation of lymphoproliferative responses in Trypanosoma cruzi infection. Immunology 104: 349-354
Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Wills-Karp M (1995) Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 182: 1527-1536
Gelvin SB (1998) The introduction and expression of transgenes in plants. Curr Opin Biotechnol 9: 227-232
Gelvin SB (2003) Agrobacterium-mediated plant transformation: the biology behind the "gene-jockeying" tool. Microbiol Mol Biol Rev 67: 16-37
Gerngross TU (2004) Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nat Biotechnol 22: 1409-1414
Giddings G, Allison G, Brooks D, Carter A (2000) Transgenic plants as factories for biopharmaceuticals. Nat Biotechnol 18: 1151-1155
Goeddel DV, Kleid DG, Bolivar F, Heyneker HL, Yansura DG, Crea R, Hirose T, Kraszewski A, Itakura K, Riggs AD (1979) Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A 76: 106-110
Goldsby RA, Kindt TJ, Osborne BA (2000) Kuby immunology 4th ed: New York: W.H. Freeman and company
Gomord V, Denmat LA, Fitchette-Laine AC, Satiat-Jeunemaitre B, Hawes C, Faye L (1997) The C-terminal HDEL sequence is sufficient for retention of secretory proteins in the endoplasmic reticulum (ER) but promotes vacuolar targeting of proteins that escape the ER. Plant J 11: 313-325
Gosset P, Tsicopoulos A, Wallaert B, Joseph M, Capron A, Tonnel AB (1992) Tumor necrosis factor alpha and interleukin-6 production by human mononuclear phagocytes from allergic asthmatics after IgE-dependent stimulation. Am Rev Respir Dis 146: 768-774
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci U S A 88: 4143-4147
Gutierrez-Ortega A, Avila-Moreno F, Saucedo-Arias LJ, Sanchez-Torres C, MA. G-L (2004) Expression of a single-chain human interleukin-12 gene in transgenic tobacco plants and functional studies. Biotechnol Bioeng 85: 734-740
Gutierrez-Ortega A, Sandoval-Montes C, de Olivera-Flores TJ, Santos-Argumedo L, Gomez-Lim MA (2005) Expression of functional interleukin-12 from mouse in transgenic tomato plants. Transgenic Res 14: 877-885
Hamza S, Chupeau Y (1993) Re-evaluation of Conditions for Plant Regeneration and Agrobacterium-Mediated Transformation from Tomato (Lycopersicon esculentum). J Exp Bot 269: 1837-1845
Haq TA, Mason HS, Clements JD, Arntzen CJ (1995) Oral immunisation with a recombinant bacterial antigen produced in transgenic plants. Science 268: 714-716
Hiatt A, Cafferkey R, Bowdish K (1989) Production of antibodies in transgenic plants. Nature 342: 76-78
Hiei YK, T., Kubo T (1997) Transformation of rice mediated by Agrobacterium tumefaciens. Plant Mol Biol 35: 205-218
Hsieh TH, Lee JT, Charng YY, Chan MT (2002) Tomato plants ectopically expressing Arabidopsis CBF1 show enhanced resistance to water deficit stress. Plant Physiol 130: 618-626
Huang Z, Dry I, Webster D, Strugnell R, Wesselingh S (2001) Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice. Vaccine 19: 2163-2121
Itakura K, Tadaaki H, Crea R, Riggs AD, Heyneker HL, Bolivar F, Boyer HW (1977) Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Biotechnology 24:84-91
Johnson IS (1983) Human insulin from recombinant DNA technology. Science 219: 632-637
Kang BY, Kim E, Kim KTS (2005) Regulatory mechanisms and their therapeutic implications of interleukin-12 production in immune cells. Cell Signal 17: 665-673
Kanno T, Naito S, Shimamoto K (2000) Post-transcriptional gene silencing in cultured rice cells. Plant Cell Physiol 41: 321-326
Kincy-Cain T, Clements JD, Bost KL (1996) Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin. Infect Immun 64: 1437-1440
Ko K, Koprowski H (2005) Plant biopharming of monoclonal antibodies. Virus Res 111: 93-100
Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170: 827-845
Kost TA (1997) Expression systems: Gene expression systems in the genomics era. Curr Opin Biotechnol 8: 539-541
Kwon TH, Seo JE, Kim J, Lee JH, Jang YS, Yang MS (2003) Expression and secretion of the heterodimeric protein interleukin-12 in plant cell suspension culture. Biotechnol Bioeng 81: 870-875
Larrick JW, Thomas DW (2001) Producing proteins in transgenic plants and animals. Curr Opin Biotechnol 12: 411-418
Lee YL, Ye YL, Yu CI, Wu YL, Lai YL, Ku PH, Hong RL, Chiang BL (2001) Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma. Hum Gene Ther 12: 2065-2079
Lee YW, Jin S, Sim WS, Nester EW (1996) The sensing of plant signal molecules by Agrobacterium: genetic evidence for direct recognition of phenolic inducers by the VirA protein. Gene 179: 83-88
Leonard P, Sur S (2003) Interleukin-12: potential role in asthma therapy. BioDrugs 2003: 1-7
Ling P, Gately MK, Gubler U, Stern AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J (1995) Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol 154: 116-127
Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vadas MA (1988) Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 167: 219-224
Ma S, Huang Y, Yin Z, Menassa R, Brandle JE, Jevnikar AM (2004) Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci U S A 105: 5680-5685
Magnuson NS, Linzmaier PM, Reeves R, An G, HayGlass K, Lee JM (1998) Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture. Protein Expr Purif 13: 45-52
Mason HS, Ball JM, Shi JJ, Jiang X, Estes MK, Arntzen CJ (1996) Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci U S A 93: 5335-5340
Mason HS, Haq TA, Clements JD, Arntzen CJ (1998) Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 16: 1336-1343
Mason HS, Lam DM, Arntzen CJ (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci U S A 89: 11745-11749
Mason HS, Warzecha H, Mor T, Arntzen CJ (2002) Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol Med 8: 324-329
Matsuo R, Kobayashi M, Herndon DN, Pollard RB, Suzuki F (1996) Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection. J Leukoc Biol 595: 623-630
McLane MP, Haczku A, van de Rijn M, Weiss C, Ferrante V, MacDonald D, Renauld JC, Nicolaides NC, Holroyd KJ, Levitt RC (1998) Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. Am J Respir Cell Mol Biol 19: 713-720
Ohya K, Itchoda N, Ohashi K, Onuma M, Sugimoto C, Matsumura T (2002) Expression of biologically active human tumor necrosis factor-alpha in transgenic potato plant. J Interferon Cytokine Res 22: 371-378
Ohya K, Matsumura T, Ohashi K, Onuma M, Sugimoto C (2001) Expression of two subtypes of human IFN-alpha in transgenic potato plants. J Interferon Cytokine Res 21: 595-602
Ou-Lee TM, Turgeon R, Wu R (1986) Expression of a foreign gene linked to either a plant-virus or a Drosophila promoter, after electroporation of protoplasts of rice, wheat, and sorghum. Proc Natl Acad Sci U S A 83: 6815-6819
Pansegrau W, Schoumacher F, Hohn B, Lanka E (1993) Site-specific cleavage and joining of single-stranded DNA by VirD2 protein of Agrobacterium tumefaciens Ti plasmids: analogy to bacterial. conjugation. Proc Natl Acad Sci U S A 90: 11538-11542
Perlak FJ, Fuchs RL, Dean DA, McPherson SL, Fischhoff DA (1991) Modification of the coding sequence enhances plant expression of insect control protein genes. Proc Natl Acad Sci U S A 88: 3324-3328
PhRMA (2004) survey:Medicines in development biotechnology. www.phrma.org
Portielje JE, Kruit WH, Eerenberg AJ, Schuler M, Sparreboom A, Lamers CH, Gratama JW, Stoter G, Huber C, Hack CE (2005) Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant. Cancer Immunol Immunother 54: 37-43
Rai M, Padh H (2001) Expression systems for production of heterologous protein. Curr Science 80: 1121-1128
Reuhs BL, Kim JS, Matthysse AG (1997) Attachment of Agrobacterium tumefaciens to carrot cells and Arabidopsis wound sites is correlated with the presence of a cell-associated, acidic polysaccharide. J Bacteriol 179: 5372-5379
Rossol S, Marinos G, Carucci P, Singer MV, Williams R, Naoumov NV (1997) Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest 99: 3025-3027
Roy EJ, Gawlick U, Orr BA, Rund LA, Webb AG, Kranz DM (2000) IL-12 treatment of endogenously arising murine brain tumors. J Immunol 165: 7293-7299
Saldarriaga OA, Perez LE, Travi BL, Melby PC (2006) Selective enhancement of the type 1 cytokine response by expression of a canine interleukin (IL)-12 fused heterodimeric DNA. Vet Immunol Immunopathol 110: 377-388
Sanford JC, Klein TM, Wolf ED, Allen N (1987) Delivery of substances into cells and tissue using a particle bombardment process. J Plant Sci Tech 5:27-37
Sgadari C, Angiolillo AL, Tosato G (1996) Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10. Blood 87: 3877-3882
Sgadari C, Farber JM, Angiolillo AL, Liao F, Teruya-Feldstein J, Burd PR, Yao L, Gupta G, Kanegane C, Tosato G (1997) Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo. Blood 89: 2635-2643
Sheng J, Citovsky V (1996) Agrobacterium-plant cell DNA transport: have virulence proteins, will travel. Plant Cell 8: 1699-1710
Sieburth D, Jabs EW, Warrington JA, Li X, Lasota J, LaForgia S, Kelleher K, Huebner K, Wasmuth JJ, Wolf SF (1992) Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 14: 59-62
Smart V, Foster PS, Rothenberg ME, Higgins TJ, Hogan SP (2003) A plant-based allergy vaccine suppresses experimental asthma via an IFN-gamma and CD4+CD45RBlow T cell-dependent mechanism. J Immunol 171: 2116-2126
Stachel SE, Messens E, Van Montagu M, Zambryski P (1985) Identification of the signal molecules produced by wounded plant cells that activate T-DNA transfer in Agrobacterium tumefaciens. Nature 318: 624-629
Staub JM, Garcia B, Graves J, Hajdukiewicz PT, Hunter P, Nehra N, Paradkar V, Schlittler M, Carroll JA, Spatola L, Ward D, Ye G, Russell DA (2000) High-yield production of a human therapeutic protein in tobacco chloroplasts. Nat Biotechnol. 18: 330-338
Steinberg FM, Raso J (1998) Biotech pharmaceuticals and biotherapy: an overview. J Pharm Pharm Sci 1: 48-59
Stern AS, Podlaski FJ, Hulmes JD, Pan YC, Quinn PM, Wolitzky AG, Familletti PC, Stremlo DL, Truitt T, Chizzonite R (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci U S A 87: 6808-6812
Stylianou E, Aukrust P, Nordoy I, Muller F, Froland SS (2000) Enhancement of lymphocyte proliferation induced by interleukin-12 and anti-interleukin-10 in HIV-infected patients during highly active antiretroviral therapy. APMIS 108: 601-607
Tang W, Samuels V, Whitley N, Bloom N, T. D, Newton RJ (2004) Post-transcriptional gene silencing induced by short interfering RNAs in cultured transgenic plant cells. Genomics Proteomics Bioinformatics 2: 97-104
Teixeira LK, Fonseca BP, Barboza BA, Viola JP (2005) The role of interferon-gamma on immune and allergic responses. Mem Inst Oswaldo Cruz 100 Suppl 1: 137-144
Temann UA, Geba GP, Rankin JA, Flavell RA (1998) Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 188: 1307-1320
Thomashow MF, Karlinsey JE, Marks JR, Hurlbert RE (1987) Identification of a new virulence locus in Agrobacterium tumefaciens that affects polysaccharide composition and plant cell attachment. J Bacteriol 169: 3209-3216
Trinchieri G (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84: 4008-4027
Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13: 251-276
Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adative immunity. Nature Rev Immunol 3: 133-146
Tzfira T, Li J, Lacroix B, Citovsky V (2004) Agrobacterium T-DNA integration: molecules and models. Trends Genet 20: 375-383
van den Eede G, Aarts H, Buhk HJ, Corthier G, Flint HJ, Hammes W, Jacobsen B, Midtvedt T, van der Vossen J, von Wright A, Wackernagel W, Wilcks A (2004) The relevance of gene transfer to the safety of food and feed derived from genetically modified (GM) plants. Food Chem Toxicol 42: 1127-1156
Vaucheret H, Beclin C, Elmayan T, Feuerbach F, Godon C, Morel JB, Mourrain P, Palauqui JC, Vernhettes S (1998) Transgene-induced gene silencing in plants. Plant J 16: 651-659
Vaucheret H, Beclin C, Fagard M (2001) Post-transcriptional gene silencing in plants. J Cell Sci 114: 3083-3091
Vaucheret H, Fagard M (2001) Transcriptional gene silencing in plants: targets, inducers and regulators. Trends Genet 17: 29-35
Velcheva M, Faltin Z, Flaishman M, Eshdat Y, Perl A (2004) A liquid culture system for Agrobacterium-mediated transformation of tomato (Lycopersicon esculentum L. Mill). Plant Sci 168: 121-130
Vervecken W, Kaigorodov V, Callewaert N, Geysens S, De Vusser K, Contreras R (2004) In vivo synthesis of mammalian-like, hybrid-type N-glycans in Pichia pastoris. Appl Environ Microbiol 70: 2639-2646
Walsh G (2005) Therapeutic insulins and their large-scale manufacture. Appl Microbiol Biotechnol 67: 151-159
Whitlow M, Bell B.A., Feng S.L., Filpula D., Hardman K.D., Hubert S.L., Rollence M.L., Wood J.F., Schott M.E., Milenic D.E. (1993) An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability. Protein Eng 6: 989-995
Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD (1998) Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261
Zambryski P, Tempe J, J. S (1989) Transfer and function of T-DNA genes from agrobacterium Ti and Ri plasmids in plants. Cell 56: 193-201
Zhang B, Yang YH, Lin YM, Rao Q, Zheng GG, Wu KF (2003) Expression and production of bioactive human interleukin-18 in transgenic tobacco plants. Biotechnol Lett 25: 1629-1635
Zheng LY, Mou L, Lin S, Lu RM, Luo EJ (2005) Enhancing DNA vaccine potency against hantavirus by co-administration of interleukin-12 expression vector as a genetic adjuvant. Chin Med J (Engl) 118: 313-319
Zhou GY, Weng J, Zeng Y, Huang SQ, Liu G (1983) Import of exogenous DNA into cotton embryos. Plant Cell 13: 369-384
Zupan JR, Zambryski P (1995) Transfer of T-DNA from Agrobacterium to the plant cell. Plant Physiol 107: 1041-1047
|